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Endometriosis: The Facts

Women of a reproductive age have a monthly cycle where their bodies experience hormonal changes to prepare for pregnancy.

Women of a reproductive age have a monthly cycle where their bodies experience hormonal changes to prepare for pregnancy. If there is no pregnancy, the thickened lining of the uterus breaks down and bleeds, releasing from the body in the form of a period.

Another word for the lining of the uterus is the endometrium. But when cells outside the uterus act like the endometrium (as in they thicken and break down once a month), the condition is called endometriosis.

Endometriosis tissue is most often found inside the pelvis, around the ovaries and fallopian tubes, on the ligaments attached to the womb and in the area between the rectum and the womb. It can, however, be found less often in other places too, including the bowel, bladder, intestines, vagina and rectum. Very rarely it can be found in other parts of the body including the skin, eyes, spine lungs and brain. In fact, according to Endometriosis UK, the only part of the body that endometriosis hasn’t been found is the spleen.

The exact number of women who are affected by endometriosis isn’t known, as many women with mild symptoms may never be diagnosed. But experts from the NHS believe around two million women in the UK have the condition, most of whom are between the ages of 25 and 40.

According to the Endometriosis SHE Trust UK, endometriosis affects millions of women all over the world. The youngest well documented diagnosed case was a girl aged just 10 years old, while the oldest was a 78-year-old woman, the charity claims.

Several theories exist about what causes the condition, including retrograde menstruation (where some of the endometrium flows backwards into the abdomen during a period), lymphatic or circulatory spread (where endometriosis tissue particles somehow get into the lymphatic system or bloodstream), exposure to certain environmental toxins and problems with the immune system.

Yet despite it being the second most common gynaecological condition in the UK, the exact cause of endometriosis is still unknown.


Endometriosis symptoms

Most women with endometriosis get pain in the area between their hips and the tops of their legs, and some experience this pain all the time, says the NHS. Other common symptoms include painful or heavy periods, bleeding between periods, pain during and after sex and conception difficulties.

The Endometriosis SHE Trust UK also lists the following as commonly reported symptoms:

  • Pain at ovulation time (usually around day 14 of your cycle, where day one is the day your period starts).

  • Bowel problems

  • Bladder problems

  • Premenstrual tension (PMT) and mood swings

  • Low energy levels

  • Insomnia

  • Swollen abdomen

  • Low body temperature

In rare cases where endometriosis tissue is found in the lungs, you may also cough up blood.

How bad your symptoms are can depend on where in your body the endometriosis tissue is, and how much endometriosis tissue you have. But having larger patches of endometriosis tissue doesn’t necessarily mean worse symptoms, as some women have no symptoms with large endometriosis patches, while others have more severe symptoms with a tiny amount of endometriosis tissue.


Endometriosis complications

Fertility problems are the main complication of having endometriosis. This is often the result of endometriosis tissue growing over the reproductive organs. If endometriosis progresses to become moderate or severe, the tissue can cause scarring (often called adhesions, these are also referred to as sticky areas of tissue that can fuse organs together). An ovary can then become wrapped in adhesions, which means the egg it releases becomes trapped and can’t move down the fallopian tube where it may be fertilised before entering the uterus.

Your chances of getting pregnant depend on how severe your endometriosis is – though it should be noted that your age makes a difference too (fertility starts to decline rapidly after the age of 38).

But generally speaking, if 100 women without endometriosis start trying for a baby, at the end of one year 84 will be pregnant. Out of the same number of women with mild endometriosis trying for a baby, 75 will be pregnant at the end of the year. This success rate declines to 50 among women with moderate endometriosis and 25 among those with severe endometriosis.

Meanwhile, if you have endometriosis tissue in an ovary, it can form ovarian cysts (in some cases these cysts can be come very large and painful).


Bladder and bowel problems

According to Endometriosis UK, the condition affecting the bladder is rare. But in such cases endometriosis tissue can be found on the outer surface of the bladder or on the inside of the bladder lining or wall. This can cause a number of symptoms such as pain when you have a full bladder, sudden urges to urinate, bladder irritation and sometimes blood in your urine during your period.

Endometriosis can also affect the bowel, where tissue is found on the surface of the bowel or when it penetrates the bowel wall. Many women with bowel endometriosis have symptoms similar to those of irritable bowel syndrome (IBS), but those symptoms are often worse during the run up to and during a period. In severe untreated cases, large patches of endometriosis tissue can block the bowel or the ureter (the tube connecting the kidney to the bladder).

There is also some evidence that women with endometriosis may have an increased risk of inflammatory bowel disease (i), as well as that of some cancers (including breast and ovarian cancer), autoimmune disorders and allergies (ii). It is not a cancerous condition, however.

The good news is endometriosis gets better without treatment in about three out of 10 cases. In a further three out of 10 cases it stays the same (that is, it doesn’t progress). But for the remaining four out of 10 cases it does get worse if left untreated.


How is endometriosis treated?

These are several treatments for endometriosis. However, there’s no cure and treatment – which aims to reduce symptoms – can often be difficult.

The type of treatment you may be offered will largely depend on how old you are and what your main symptom is. If your main symptom is pain – especially during your period – treatment may include painkillers or hormones to limit or stop your body producing oestrogen (oestrogen makes endometriosis tissue thicken and break down).

But if your main concern is that you’re having difficulty getting pregnant, you may be offered surgery. If your symptoms are mild and you don’t have fertility problems, or you’re approaching the menopause, you may get better without any form of treatment.

  • Painkillers
    Normally, the type of painkiller used to treat endometriosis pain is an anti-inflammatory painkiller (or non-steroidal anti-inflammatory drug – NSAID) such as ibuprofen. Other painkillers such as paracetamol can be used too, but usually only if NSAIDs cause side effects (paracetamol is considered less effective than NSAIDs, while stronger paracetamol-based painkillers such as co-codamol can cause constipation thanks to the fact that they contain codeine – and constipation can make endometriosis symptoms worse).

    Endometriosis UK also recommends a simple hot water bottle or hot bath to help reduce pain, as well as TENS machines (these are thought to work by blocking pain messages with electrical pulses).

  • Hormones
    Hormone treatments can reduce the symptoms of endometriosis because they make your body produce little or no oestrogen.

    These treatments include contraceptives such as the contraceptive pill or patch, or the levonorgestrel-releasing intrauterine system (LNG-IUS), as well as hormones called gonadotrophin-releasing hormone (GnRH) analogues, progestogens and antiprogestogens.

    All of these treatments can have potential side effects and, in the case of the contraceptive treatments, will prevent you temporarily from getting pregnant (the others may also reduce your chance of pregnancy while you’re using them). According to the NHS, they are equally effective at treating endometriosis.

  • Surgery
    Surgically removing or destroying areas of endometriosis tissue can improve the symptoms of endometriosis as well as improve fertility. If you want to have children, there are two options – laparoscopy and laparotomy. Both are performed under general anaesthetic, with laparotomy used for more severe and extensive cases (laparoscopy is a simpler operation, which is often referred to as keyhole surgery). If you don’t want any more children and other treatments haven’t worked, you may be advised to have a hysterectomy, where the uterus is removed. There are, however, several important implications of having a hysterectomy that you should discuss with your GP or gynaecologist before making a decision.


Endometriosis and lifestyle

Having endometriosis can have a significant impact on your day-to-day life. As well as having to cope with intermittent or even permanent pain, you may also experience fatigue, low energy levels and depression. As the Endometriosis SHE Trust UK puts it, although endometriosis isn’t a killer disease, it can make a woman’s life an utter misery.

Besides conventional treatments, there are some things you can do where your lifestyle is concerned. Some studies, for instance, suggest certain foods may increase the risk of endometriosis.

One study suggests women who eat a lot of green vegetables and fresh fruit are significantly less likely to have endometriosis, whereas those who eat a lot of beef and ham have an increased risk (iii). Researchers elsewhere claim drinking alcohol may increase the risk of endometriosis (iv), particularly among women with fertility problems (v). And certain chemicals such as polychlorinated biphenyls (PCBs) – found in pesticides – may also increase your susceptibility towards developing endometriosis (vi).


Endometriosis diet

As a result of these and other studies, many natural health and nutrition practitioners make various dietary recommendations for women with endometriosis, including the following:

  • Eat as much fruit and as many vegetables as possible (fresh and organic, ideally).

  • Include oily fish in your diet on a regular basis (women of reproductive age are recommended to eat no more than two portions a week).

  • When eating meat, try to make sure it’s organic and hormone free.

  • Drink plenty of water but avoid alcohol and other stimulants such as caffeine and sugar.

  • Eat lots of iron-rich foods if you have heavy periods (find plant-sourced iron in green leafy veg, dried apricots, lentils, pumpkin seeds and brown rice, and animal-sourced iron in meat, eggs and fish).

  • Also eat lots of fibre to keep your digestive system healthy (having lots of fruit and veg will help, but you can also get fibre from whole grains, beans and pulses).

Meanwhile, there’s also some evidence that exercise could help reduce the risk of endometriosis, since it’s thought that regular exercise helps to lower the amount of oestrogen in the body. This is backed up by at least one study, which suggests a link between a significantly reduced risk of endometriosis and regular high-intensity physical activity (vii).


Natural support for endometriosis

As well as eating healthily and being physically active, there are several natural supplements you could take that might support your body and potentially ease the symptoms of endometriosis, including the following:


Fish oils

A source of omega-3 fatty acids, fish oils are widely thought to have an anti-inflammatory effect on the body. Omega-3 fatty acids may also help reduce menstrual problems such as menstrual pain (dysmenorrhoea) by having an effect on prostaglandins and other factors involved in pain and inflammation.

One study suggests taking omega-3 fatty acids for two months may reduce menstrual pain significantly (ix), while another has found fish oils and vitamin B12 supplements may have a similar effect (ix).


Magnesium

This mineral may also be useful for period pain, with studies suggesting it may significantly improve symptoms (one group of researchers claim magnesium reduces levels of prostaglandin F2 alpha, which is a chemical involved in period pain) (x). Taking a magnesium supplement may also benefit the seven out of 10 women thought to be getting insufficient magnesium from their diet.


Vitamin C

This antioxidant vitamin is required for the growth and repair of tissues in all parts of the body, with many experts believing it’s important for healing. Vitamin C may be helpful for endometriosis as it’s involved in the way the immune system works (some experts believe problems with immune function may play a part in the development of the condition). One study also suggests an antioxidant supplement containing vitamins C and E may help reduce chronic pain associated with endometriosis (xi).


Anthocyanidins

These are naturally occurring plant substances that belong to a group of chemicals called flavonoids. They’re found in the pigments of dark and richly coloured fruits such as blueberries, blackberries, raspberries and red grapes, as well as other sources including grapeseed extract. Anthocyanidins may be helpful for endometriosis as they may help increase the amount of vitamin C in the body and have also been shown to block the release of prostaglandins, which are involved in pain and inflammation (xii).


Myo-inositol

A vitamin-like substance (also sometimes called a pseudovitamin) found in many natural sources, myo-inositol – often called simply inositol – is a carbohydrate with a molecular structure similar to that of glucose. Myo-inositol may be helpful if you’re having difficulties conceiving, as there’s evidence to suggest it may help with menstrual regularity, ovulation and higher quality eggs when taken in combination with the B vitamin folic acid (xiii).

 

References:

  1. , , , et al; Increased risk of inflammatory bowel disease in women with endometriosis: a nationwide Danish cohort study. Gut. ;61(9):1279-83 doi: 10.1136/gutjnl-2011-301095. Epub 2011 Dec 19.

  2. , , , et al; Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies. Lancet Oncol. Apr;13(4):385-94. , ; Endometriosis. Lancet. Nov 13-19;364(9447):1789-99.

  3. , , et al. Selected food intake and risk of endometriosis. Hum Reprod. Aug;19(8):1755-9.

  4. , , , , . MAST scores, alcohol consumption, and gynecological symptoms in endometriosis patients. Alcohol Clin Exp Res.

  5. , , . Infertility in women and moderate alcohol use. Am J Public Health. ;84:1429-1432.

  6. , , , et al.Environmental PCB exposure and risk of endometriosis. Hum Reprod. ;20:279-285.

  7. , .Recreational physical activity and endometrioma risk. Am J Epidemiol. Jul 15;158(2):156-64.

  8. , , , et al.Supplementation with omega-3 polyunsaturated fatty acids in the management of dysmenorrhea in adolescents. Am J Obstet Gynecol. ;174:1335-1338.

  9. , , . Menstrual discomfort in Danish women reduced by dietary supplements of omega-3 PUFA and B12 (fish oil or sea oil capsules). Nutrition Research. Volume 20, Issue 5, Pages 621-631.

  10. , , , et al.Magnesium—a new therapeutic alternative in primary dysmenorrhea [translated from German]. Zentralbl Gynakol. ;111:755-760. , . The therapeutic effects of magnesium in dysmenorrhea [in German; English abstract]. Schweiz Rundsch Med Prax. ;79:491-494.

  11. , , et al.Antioxidant supplementation reduces entometriosis-related pelvic pain in humans. Transl Res. ;151(3):189-95.

  12. , , , , .Anti-inflammatory effect of procyanidins from wild grape (Vitis amurensis) seeds in LPS-induced RAW 264.7 cells. Oxidative Medicine and Cellular Longevity, Article ID 409321, 11 pages, 2013.5.

  13. , et al. Randomized, double-blind placebo-controlled trial: Effects of Myo-inositol on Ovarian Function and Metabolic Factors in Women with PCOS. Eur Rev Med Pharmacol Sci. ;11(5):347-54.
    C, et al. Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double blind trial. Eur Rev Med Pharmacol Sci. ;15(5):509-14.


Disclaimer: The information presented by Nature's Best The Pharmacy is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.